Peptic Ulcer Diseases (Pud) Treatment Using Ocimum Gratissimum
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چکیده
Methanol leaf extract of Ocimum gratissimum was investigated for gastroprotective properties. The anti-ulcer effect was evaluated in three experimental ulcer models induced by ethanol, indomethacin and hypothermic restraint stress in rats. Anti-ulcer related properties of the extract of the plant such as gastrointestinal transit and the activity of the isolated gut tissue preparation of guinea pig and rabbit were as well determined using 200, 400 and 800 mg/kgof the extract which showed significant level of (p˂0.05). This reduced the ulcer to some extent. The extract showed higher level of gastroprotective properties of ethanolinduced rats and indomethacin treated rats. The motility rate of the rats was significant (p˂0.05) reduced by the mice. On the rabbit jejunum, ME produced a concentration-dependent relaxation and inhibited contractile responses. The extract, ME on guinea pig ileum but inhibited the contractions produced by histamine. The extract showed no sign of acute toxicity of the rats. The result showed that methanol leaf extract of Ocimum gratissimum is of high level of protective property to ulcerations and could be used for the treatment of peptic ulcer diseases.
منابع مشابه
Peptic Ulcer Diseases in Korea
Peptic ulcer disease (PUD) is one of the most commonly encountered gastroenterologic diseases in Korea. The trend in diagnosis and treatment of PUD in Korea has changed in the past decade with the introduction of endoscopy and potent acid suppressants such as proton pump inhibitors. The discovery of Helicobacter pylori has opened a new era for the understanding of pathogenesis and management of...
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